Fabio Luis Forti

Email:

flforti@iq.usp.br

Informações Gerais / General Information

Função:

Professor Associado

Departamento:

Departamento de Bioquímica

Telefone Direto:

3091-9905

Telefone do Laboratório:

3091-2172

Bloco:

9i

Sala:

924

Informações sobre Pesquisa / Research Information

Área(s) de Pesquisa/ Research Area(s):

Biologia Molecular e Celular/ Molecular and Cellular Biology

Bioquímica de Doenças Humanas/ Biochemistry of Human Diseases

Genômica, Proteômica e Bioinformática/ Genome, Proteome and Bioinformatics

Membranas, Sinalização e Tráfego/ Membranes, Signalling and Traffic

Linha(s) de Pesquisa/ Research Topic(s):

Bases Moleculares da Expressão e Função Gênica/ Molecular Basis of Gene Expression and Function

Biotecnologia: Terapia Celular, Desenvolvimento de Vacinas e Biofármacos/ Biotechnology: Cell Therapy, Development of Vaccines and Biopharmaceuticals

Controle do Ciclo Celular, Sinalização e Câncer/ Cell Cycle Control, Signaling and Cancer

Tema da Pesquisa/ Research Topics:

Rho GTPases e Tirosina Fosfatases: Funções Celulares e Moleculares em Doenças Humanas

Abas

Apresentação

Resumo: As respostas de células eucarióticas frente a agentes endógenos e exógenos que causam danos no DNA (genotóxicos) dependem do acionamento rápido e eficiente de vias de sinalização e/ou redes integradas de sinalização que levam ao reparo do material genético lesado e a manutenção da estabilidade/integridade do mesmo possibilitando a sobrevivência e proliferação celular. Estas respostas são mediadas por mecanismos de Transdução de Sinais, muitos dos quais envolvem as famílias de enzimas Rho GTPases e Proteínas Tirosina Fosfatases e Quinases.

Assim sendo, a Regulação do Ciclo Celular e de Mecanismos Moleculares de Manutenção da Estabilidade Genômica de células eucariótics são os principais interesses de nosso laboratório em diferentes contextos fisiopatológicos. Para isso, uma ampla gama de abordagens Bioquímicas, de Proteômica, de Biologia Celular e Molecular, de Biologia de Sistemas e Bioinformática (Interação Proteína-Proteína ou Interactomas) são usadas para se investigar as funções moleculares e celulares destas enzimas. Os modelos biológicos que usamos em nossos estudos compreendem linhagens celulares normais e tumorais humanas (melanoma, glioma, câncer de cervix, mama, pulmão e próstata, leucemias) a agentes externos (físicos e químicos) causadores de danos no DNA genômico que mimetizam terapias e tratamentos anticâncer.

Um maior entendimento e conhecimento de redes de sinalização intracelular controladas por estas enzimas nos levarão ao melhor planejamento e intervenção molecular por pequensa moléculas (drogas) que possam viabilizar tratamentos terapêuticos, usando pré-sensibilizações combinadas de quimioterápicos associadas ou não com radioterapia, contra os diferentes tipos de câncer humanos de maior incidência na população.

EQUIPE do LSSB em 2016

MAIS INFORMAÇÕES VISITE NOSSA:

Publicações Mais Recentes e Citadas no Web of Science

Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism

Authors: Fachi, Jose Luis; Felipe, Jaqueline de Souza; Pral, Lais Passariello; Forti, Fabio Luis; ... Ramirez Vinolo, Marco Aurelio; see more

Published: 2019 in Cell Reports

DOI: 10.1016/J.CELREP.2019.03.054

57 Citations

Protein Disulfide Isomerase Is Required for Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration, Nox1 NADPH Oxidase Expression, and RhoGTPase Activation

Authors: Pescatore, Luciana A.; Bonatto, Diego; Forti, Fabio L.; ... Laurindo, Francisco R. M.; see more

Published: Aug 2012 in Journal of Biological Chemistry

DOI: 10.1074/JBC.M112.394551

54 Citations

A Novel Intracellular Peptide Derived from G(1)/S Cyclin D2 Induces Cell Death

Authors: de Araujo, Christiane B.; Russo, Lilian C.; Castro, Leandro M.; Forti, Fabio Luis; ... Ferro, Emer S.; see more

Published: Jun 2014 in Journal of Biological Chemistry

DOI: 10.1074/JBC.M113.537118

29 Citations

ACTH receptor: Ectopic expression, activity and signaling

Authors: Forti, Fabio Luis; Dias, Matheus H. S.; Armelin, Hugo Aguirre

Published: 2006 in Molecular and Cellular Biochemistry

DOI: 10.1007/S11010-006-9237-0

28 Citations

Rho Signaling Pathway and Apical Constriction in the Early Lens Placode

Authors: Borges, Ricardo Moraes; Lamers, Marcelo Lazzaron; Forti, Fabio Luis; ... Irene Yan, Chao Yun; see more

Published: 2011 in Genesis: The Journal of Genetics and Development

DOI: 10.1002/DVG.20723

26 Citations

Neurolysin Knockout Mice Generation and Initial Phenotype Characterization

Authors: Cavalcanti, Diogo M. L. P.; Castro, Leandro M.; Rosa Neto, Jose C.; Forti, Fabio L.;... Ferro, Emer S.; see more

Published: May 2014 in Journal of Biological Chemistry

DOI: 10.1074/JBC.M113.539148

25 Citations

ACTH promotion of p27(Kip1) induction in mouse Y1 adrenocortical tumor cells is dependent on both PKA activation and Akt/PKB inactivation

Authors: Forti, FL; Schwindt, TT; Moraes, MS; ... Armelin, HA; see more

Published: 2002 in Biochemistry

DOI: 10.1021/BI0258086

24 Citations

Proliferative signaling initiated in ACTH receptors

Authors: Lotfi, CFP; Lepique, AP; Forti, FL; ... Armelin, HA; see more

Published: Oct 2000 in Brazilian Journal of Medical and Biological Research

DOI: 10.1590/S0100-879X2000001000002

24 Citations

Rac1 GTPase-deficient HeLa cells present reduced DNA repair, proliferation, and survival under UV or gamma irradiation

Authors: Espinha, Gisele; Osaki, Juliana H.; Magalhaes, Yuli T.; Forti, Fabio Luis

Published: 2015 in Molecular and Cellular Biochemistry

DOI: 10.1007/S11010-015-2388-0

21 Citations

Deconstructing the molecular mechanisms of cell cycle control in a mouse adrenocortical cell line: Roles of ACTH

Authors: Forti, F. L.; Rocha, K. M.; Lepique, A. P.; Armelin, H. A.

Published: 2003 in Microscopy Research and Technique

DOI: 10.1002/JEMT.10336

19 Citations

Signal transduction in G(0)/G(1)-arrested mouse Y1 adrenocortical cells stimulated by ACTH and FGF2

Authors: Forti, F. L.; Lepique, A. P. ; Moraes, M. S. ; Armelin, H. A.

Published: 2000 in Endocrine Research

DOI: 10.3109/07435800009048605

17 Citations

Proteomic, Cellular, and Network Analyses Reveal New DUSP3 Interactions with Nucleolar Proteins in HeLa Cells

Authors: Panico, Karine; Forti, Fabio Luis

Published: 2013 in Journal of Proteome Research

DOI: 10.1021/PR400867J

16 Citations

A Cyclin D2-derived peptide acts on specific cell cycle phases by activating ERK1/2 to cause the death of breast cancer cells

Authors: Russo, Lilian C.; Araujo, Christiane B.; Iwai, Leo K.; ... Forti, Fabio L.; see more

Published: 2017 in Journal of Proteomics

DOI: 10.1016/J.JPROT.2016.06.028

14 Citations

Fibroblast growth factor 2 restrains ras-driven proliferation of malignant cells by triggering RhoA-mediated senescence

Authors: Costa, Erico T.; Forti, Fabio L.; Matos, Tatiana G. F.; ... Armelin, Hugo A.; see more

Published: Aug 2008 in Cancer Research

DOI: 10.1158/0008-5472.CAN-08-0342

13 Citations

Intracellular Peptides in Cell Biology and Pharmacology

Authors: de Araujo, Christiane B.; Heimann, Andrea S.; Remer, Ricardo A.; Forti, Fabio L.; ... Ferro, Emer S.; see more

Published: Apr 2019 in Biomolecules

DOI: 10.3390/BIOM9040150

12 Citations

Lista Completa de Publicações:

https://www.ncbi.nlm.nih.gov/pubmed/?term=forti+fl

Introduction

ABSTRACT: The responses of eukaryotic cells to endogenous and exogenous agents that cause DNA damage (genotoxic) depend on the fast and efficient activation of signaling pathways and/or integrated signaling networks that lead to the repair of lesioned genetic material and maintenance of genetic stability/integrity enabling cell survival and proliferation. These responses are mediated by Signal Transduction mechanisms, many of which involve the Rho GTPase, Protein Tyrosine Phosphatases and Kinase families of enzymes.

Therefore, Cell Cycle Regulation and Molecular Mechanisms for the Maintenance of Genomic Stability of eukaryotic cells are the main interests of our laboratory in different pathophysiological contexts. For these purposes, a wide range of Biochemical, Proteomics, Cellular and Molecular Biology, Systems Biology and Bioinformatics (Protein-Protein Interaction or Interactomes) approaches are used to investigate the molecular and cellular functions of these enzymes. The biological models we use in our studies range from human normal and tumor cell lines (melanoma, glioma, cancer of the cervix, breast, lung and prostate, leukemia) to external agents (physical and chemical) causing damage to genomic DNA that mimic therapies and anti-cancer treatments.

A greater understanding and knowledge of intracellular signaling networks controlled by these enzymes will lead us to better planning molecular interventions by small molecules (drugs) that can enable therapeutic treatments, using combined pre-sensitization of chemotherapy agents associated or not with radiotherapy, against the different types of human cancers with the highest incidence in the population.

Peer-Reviewed Publications Most Cited in Web of Science

Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism

Authors: Fachi, Jose Luis; Felipe, Jaqueline de Souza; Pral, Lais Passariello; ... Ramirez Vinolo, Marco Aurelio; see more

Published: 2019 in Cell Reports

DOI: 10.1016/J.CELREP.2019.03.054

57 Citations

Protein Disulfide Isomerase Is Required for Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration, Nox1 NADPH Oxidase Expression, and RhoGTPase Activation

Authors: Pescatore, Luciana A.; Bonatto, Diego; Forti, Fabio L.; ... Laurindo, Francisco R. M.; see more

Published: Aug 2012 in Journal of Biological Chemistry

DOI: 10.1074/JBC.M112.394551

54 Citations

A Novel Intracellular Peptide Derived from G(1)/S Cyclin D2 Induces Cell Death

Authors: de Araujo, Christiane B.; Russo, Lilian C.; Castro, Leandro M.; ... Ferro, Emer S.; see more

Published: Jun 2014 in Journal of Biological Chemistry

DOI: 10.1074/JBC.M113.537118

29 Citations

ACTH receptor: Ectopic expression, activity and signaling

Authors: Forti, Fabio Luis; Dias, Matheus H. S.; Armelin, Hugo Aguirre

Published: 2006 in Molecular and Cellular Biochemistry

DOI: 10.1007/S11010-006-9237-0

28 Citations

Rho Signaling Pathway and Apical Constriction in the Early Lens Placode

Authors: Borges, Ricardo Moraes; Lamers, Marcelo Lazzaron; Forti, Fabio Luis; ... Irene Yan, Chao Yun; see more

Published: 2011 in Genesis: The Journal of Genetics and Development

DOI: 10.1002/DVG.20723

26 Citations

Neurolysin Knockout Mice Generation and Initial Phenotype Characterization

Authors: Cavalcanti, Diogo M. L. P.; Castro, Leandro M.; Rosa Neto, Jose C.; ... Ferro, Emer S.; see more

Published: May 2014 in Journal of Biological Chemistry

DOI: 10.1074/JBC.M113.539148

25 Citations

ACTH promotion of p27(Kip1) induction in mouse Y1 adrenocortical tumor cells is dependent on both PKA activation and Akt/PKB inactivation

Authors: Forti, FL; Schwindt, TT; Moraes, MS; ... Armelin, HA; see more

Published: 2002 in Biochemistry

DOI: 10.1021/BI0258086

24 Citations

Proliferative signaling initiated in ACTH receptors

Authors: Lotfi, CFP; Lepique, AP; Forti, FL; ... Armelin, HA; see more

Published: Oct 2000 in Brazilian Journal of Medical and Biological Research

DOI: 10.1590/S0100-879X2000001000002

24 Citations

Rac1 GTPase-deficient HeLa cells present reduced DNA repair, proliferation, and survival under UV or gamma irradiation

Authors: Espinha, Gisele; Osaki, Juliana H.; Magalhaes, Yuli T.; Forti, Fabio Luis

Published: 2015 in Molecular and Cellular Biochemistry

DOI: 10.1007/S11010-015-2388-0

21 Citations

Deconstructing the molecular mechanisms of cell cycle control in a mouse adrenocortical cell line: Roles of ACTH

Authors: Forti, F. L.; Rocha, K. M.; Lepique, A. P.; Armelin, H. A.

Published: 2003 in Microscopy Research and Technique

DOI: 10.1002/JEMT.10336

19 Citations

Signal transduction in G(0)/G(1)-arrested mouse Y1 adrenocortical cells stimulated by ACTH and FGF2

Authors: Forti, F. L.; Lepique, A. P. ; Moraes, M. S. ; Armelin, H. A.

Published: 2000 in Endocrine Research

DOI: 10.3109/07435800009048605

17 Citations

Proteomic, Cellular, and Network Analyses Reveal New DUSP3 Interactions with Nucleolar Proteins in HeLa Cells

Authors: Panico, Karine; Forti, Fabio Luis

Published: 2013 in Journal of Proteome Research

DOI: 10.1021/PR400867J

16 Citations

A Cyclin D2-derived peptide acts on specific cell cycle phases by activating ERK1/2 to cause the death of breast cancer cells

Authors: Russo, Lilian C.; Araujo, Christiane B.; Iwai, Leo K.; ... Forti, Fabio L.; see more

Published: 2017 in Journal of Proteomics

DOI: 10.1016/J.JPROT.2016.06.028

14 Citations

Fibroblast growth factor 2 restrains ras-driven proliferation of malignant cells by triggering RhoA-mediated senescence

Authors: Costa, Erico T.; Forti, Fabio L.; Matos, Tatiana G. F.; ... Armelin, Hugo A.; see more

Published: Aug 2008 in Cancer Research

DOI: 10.1158/0008-5472.CAN-08-0342

13 Citations

Intracellular Peptides in Cell Biology and Pharmacology

Authors: de Araujo, Christiane B.; Heimann, Andrea S.; Remer, Ricardo A.; ... Ferro, Emer S.; see more

Published: Apr 2019 in Biomolecules

DOI: 10.3390/BIOM9040150

12 Citations

Complete List of Published Work in My Bibliography:

https://www.ncbi.nlm.nih.gov/pubmed/?term=forti+fl

Fabio Luis Forti

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Fabio Luis Forti

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